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A clinical study published in January of 2015 shows that prostate cancer cells could be stopped in their tracks for up to a year by alternatively overwhelming and depriving them of testosterone. Now, one man’s success story is proving the approach to be very promising indeed for men diagnosed with prostate cancer.

The Conventional Treatment Method

Currently, doctors try to kill cancer cells in the prostate by ‘starving’ them of testosterone (referred to as ‘castrating therapy’), since it is believed that they feed off of this hormone. However, in most cases, this approach only holds cancer cells at bay up to a certain point, after which they rebound and testosterone deprivation no longer has an effect. The medical term for this is CRPC (castration-resistant prostate cancer).

A New Idea: The Study

Researchers of the 2015 study asked themselves what might happen to cancer cells if they overloaded them with testosterone instead; the results are very interesting! (1)


In a preliminary study, 16 men with CRPC were treated with a shot of testosterone for 28 days as well as a pill for the first 14 of those days. Then after 3 cycles, they were also given the conventional testosterone-depleting therapy. The overall effect was rapid switches from extremely high to extremely low testosterone levels. The researchers called this approach Bipolar Androgen Therapy (BAT for short).

The Results

Out of the 16 men, all of them became responsive to conventional therapy after BAT. 7 of them showed decreased cancer cell count from BAT alone, and 4 men ended up being treated with BAT for over 1 year. However, in all cases, the new treatment eventually lost its effectiveness.

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A New Success Story

Professory Sam DenMeade of John Hopkins University School of Medicine led a follow-up clinical study with 47 male participants using the same BAT method. He released a statement saying, “I think we may have cured one man whose PSA dropped to zero after three months and has remained so now for 22 cycles. His disease has all disappeared.”

The other participants also showed tumor shrinkage and a slowing of the spread of cancer, as reported at a symposium on Molecular Targets and Cancer Therapeutics in Munich, Germany (2).

What does this mean for someone with prostate cancer?

The BAT method looks like it could be used to treat prostate cancer that’s resistant to conventional treatment methods. It may open up a second chance for men whose bodies aren’t responding to their doctor’s methods.

The next step for this new approach to testosterone involves organizing larger studies with more participants. With more information, the medical and scientific communities will be able to better integrate this new treatment into cancer-fighting methods.

For more information about prostate cancer, including signs and symptoms, watch this short video:

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Source:

(1) https://www.ncbi.nlm.nih.gov/pubmed/25568070

(2) http://www.telegraph.co.uk/science/2016/11/30/man-cured-prostate-cancer-doctors-shock-tumour-death-testosterone/

Image Source:

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