Posted on: June 5, 2018 at 10:48 am
Last updated: June 19, 2018 at 11:10 am

Life is often fraught with stress, and the physical, emotional, and mental stressors we encounter daily can have a significant impact on our health. As more patients present with fatigue and stress, and a broad array of other symptoms such as low libido, poor sleep, weakness, poor immune function, and the dreaded brain fog it is extremely important to address stress-related pathologies.

Taking a good look into the bodies hypothalamic pituitary adrenal, or HPA axis, we can see how this adrenal glands system is developed to help you handle stress appropriately, actively mitigating the effects of stress and returning your body to a state of healthy system homeostasis. However, as is the case for many people in our hectic world, too many daily stressors can throw this system out of balance, causing you to suffer health problems from chronic stress exposure and adrenal exhaustion.

This guide can help you to understand better the importance of a healthy HPA axis and how to keep it in balance naturally by ensuring your body receives the nutrients and rejuvenation it needs most during critical moments of stress in our lives.

HPA Axis


Understanding Your HPA Axis

The HPA axis handles the body’s biological response to stress and anxiety. Consisting of a complicated set of hormone-related signals between the hypothalamus, the pituitary gland, and the adrenal glands, the HPA axis regulates everything from the libido to your metabolism and is the key player in determining how the body will secrete hormones.

The Hypothalamus is located just above the brainstem and links the nervous system to the endocrine system and is primarily involved in the function of the metabolism.

The Pituitary Gland is also located at the top of the brain stem just below the hypothalamus and is in charge of releasing the proper hormones to keep the body normalized and in homeostasis.

The Adrenal Glands are located just on top of the kidneys. The purpose of these glands is to release several hormones related to stress, blood pressure, and sex hormones.

Claim Your FREE Copy of The Easy 5-Ingredient Ketogenic Diet Cookbook Now!


When the HA axis is chronically impacted by stress, biological resilience is eroded, and our metabolic reserve and long-term capacity to respond to change is impeded causing changes in hormonal outputs, such as cortisol, that can negatively impact our sleep, blood sugar levels, mood, fertility and many other vital functions.

Every time you encounter a stressor, your body releases cortisol for several hours afterward, causing the concentration in your blood to reach dangerous levels. When this happens, your HPA axis kicks into overdrive. Any subsequent stress responses at this point can trigger the excessive release of alarm chemicals in your brain. Continued exposure to high levels of these chemicals can impact your mental and physical health.

Natural Ways to Restore Your Healthy HPA Axis

Although you cannot completely stop stress and anxiety from entering your life, you can take steps to keep your HPA axis healthy despite demands on this system. Here are a few ways to accomplish this goal.



Adaptogens are natural health substances that help your HPA axis activate and return to a balanced state without putting too much extra stress on your body. You can acquire all of the key stress management adaptogens from Metagenics line of supportive formulas. These formulas provide nutritional support for the complete care of your adrenal support gland system and help you relax in the face of daily stressors.


When your body lacks key nutrients that are absent from your daily diet, your ability to handle stress and anxiety markedly decreases. You can improve your stress management abilities by committing to a diet with the right level of calories and nutrients for your body type and activity levels. Make sure that the foods you eat each day provide at least 100 percent of the vitamins and minerals you need to thrive.

Lifestyle Changes

Eating regular meals, completing daily exercise routines and keeping a positive attitude can all go a long way in keeping your HPA axis healthy. As you make lifestyle changes, you will likely feel a difference in the way you feel, both mentally and physically. You may notice you have more energy and can tolerate stressors that come your way much easier while finding calm faster than ever before. When paired with a healthy diet and adaptogen formulas, you can achieve true balance day after day.



How Prime Wellness Can Help

If you are ready to help your body remain healthy in the face of stress and anxiety, partner with Prime Wellness, your leading Metagenics product provider, to obtain the support you need. With stress management adaptogens from Metagenics, such as Adreset, you can achieve systemic homeostasis and keep your HPA axis healthy and be functioning at its prime.

Call our office or visit our website to book an appointment today.

Dr. Austin
Naturopathic Doctor
Dr. Austin received her Bachelor's degree in health science, as well as her naturopathic degree in Canada prior to moving to San Diego. She specializes in hormones with an emphasis on endocrine metabolism, thyroid disorders, and menopause using lifestyle medicine and natural bio-identical hormone replacement therapy. She has a passion for teaching her patients how all hormones work together to create optimal health and educating on how hormone imbalances affect mood, digestion, sleep, libido, appetite, body composition, energy, and heart health. Recently receiving her MLA in lipidology, she counsels many people on how to prevent heart disease and what medications and supplements are best for treatment in cholesterol disorders.

A quick note from our founders

Claim Your FREE Copy of The Easy 5-Ingredient Ketogenic Diet Cookbook Now!

Discover 131 delicious fat-shredding keto recipes inside this special edition of this New York Times bestseller… plus more. And today we’re GIVING it away 100% FREE!

Get free book