Posted on: March 9, 2016 at 11:34 am
Last updated: September 22, 2017 at 1:39 pm

 Republished with permission from

Zinc is a mineral essential for immune function, growth, wound healing, reproduction, protein structure, neurotransmitter secretion and insulin secretion, and supports hundreds of chemical reactions.1-3

Zinc Bioavailability


Zinc-rich foods include beef, oysters, crab, veal, lamb, pumpkin and sesame seeds, pine nuts, peanuts, soybeans, cashews, wild rice, oats and mushrooms.4 However, zinc-rich plant foods also contain substances that inhibit zinc absorption, phytate in particular.5,6 It is important to note, however, that phytate has beneficial health effects despite its tendency to lower zinc absorption. Phytate is a storage form of phosphorus and minerals in plant seeds. Originally viewed as an “anti-nutrient,” its beneficial actions were eventually discovered, such as antioxidant and anti-cancer effects. The presence of phytate also reduces glycemic effects of the foods it is present in, and may bind toxic metals, reducing our absorption of these harmful substances. Preliminary research has also suggested that phytate could help to prevent kidney stones and vascular calcification. Grains, beans, seeds, and nuts are the foods highest in phytate.7

In addition to phytate, a number of other factors reduce zinc absorption, including older age, iron, calcium, protein quality, protein intake and folic acid.8-11 Zinc can be lost in food milling and cooking processes, eventually resulting in a low consumption of zinc.

Zinc Status in Vegetarians and Vegans


A 2013 review of 34 studies concluded that zinc status is lower in vegetarians than omnivores; especially for females and vegans.12 Zinc requirements for those on a completely plant-based diet are estimated to be about 50 percent higher than the standard recommendations of 12 mg/day for females, 16.5 mg/day for males.1,2,13 Therefore, in addition to eating natural foods rich in zinc, it is reasonable to take extra supplemental zinc to assure adequacy on a vegan or near-vegan diet.

Zinc May Protect Against Depression

Zinc is a crucial nutrient for the brain; as mentioned above, zinc is needed for neurotransmitter release.3,14 Zinc may also act to reduce oxidative stress in the brain.14 Low zinc levels could potentially lead to a tendency toward anxiety and depression.  In scientific studies, blood zinc concentrations are consistently lower in depressed vs. control subjects. Furthermore, the severity of depression was found to increase with the magnitude of the zinc deficiency.15 Because of these findings, zinc supplementation is being investigated as an adjunct treatment for depression, with promising results.16 I have observed some female vegans, in my medical practice, who developed depression and anxiety which both resolved after supplementing zinc. The association between low zinc and depression appears to be stronger in women compared to men.14

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Zinc and The Prostate

Normal prostate cells contain higher levels of zinc than any other body tissue. However, if prostate cells become cancerous, they lose their ability to accumulate zinc.17,18 There is evidence that zinc has anti-cancer effects in the prostate, however, the relationship between zinc and prostate cancer risk is somewhat unclear.19 Some studies have reported increased cancer risk,20-24 some have reported decreased risk25-28 and others found no relationship at all.8,29

One study, which placed mice on one of three different diets—zinc-deficient, normal, and supplemented, suggested that optimal levels of zinc are protective, but deficiency or excess promotes prostate tumor growth.30

This is relevant for humans too. The VITAL study followed over 35,000 men for 3.5 years, who completed a questionnaire asking about their supplement use over the previous 10 years. Men who had been supplementing with 15 mg of zinc or more per day had a 66 percent decrease in the risk of advanced prostate cancer compared to men who didn’t supplement. There was no association between zinc supplements and overall prostate cancer—except in men who ate more vegetables. Importantly, the authors found that men who both supplemented 15 mg or more of zinc per day and had a higher intake of vegetables did have a reduced risk of overall prostate cancer. However, men taking the same amount of supplemental zinc with a lower intake of vegetables did not reduce their risk.26 Another study found that long-term (10 or more years) supplementation with zinc was associated with a 53 percent reduction in breast cancer risk.31 This research suggests supplementing with zinc most likely is of significant benefit, especially in those that eat a healthful vegan or near-vegan diet.

Symptoms of Zinc Deficiency




This is a medical term used for improper functioning of the reproductive system that results in a defect in the proper operation of gonads (ovaries or testes). The gonads have two functions: to produce hormones and to produce eggs or sperm. The deficiency of sexual and reproductive hormones can result in defective primary or secondary sexual development. This is a serious disorder that can be avoided by consuming zinc-rich foods.

Skin Problems

Zinc deficiency can have a bad effect on skin’s health. The skin can turn pale or rough. Stretch marks, acne, and greasy skin are also possible symptoms of zinc deficiency. Zinc performs collagen synthesis which helps in the healing process of wounds on the skin. There is evidence that suggests zinc can assist in the management of herpes types 1 and 2.

Emotional Instability

Zinc deficiency can affect your brain, which can lead to many emotional disturbances in your daily life. Anger, sudden fright, depression, and low confidence are some symptoms that can occur, while the most common symptom is frequent mood changes. If zinc deficiency is not paid proper attention to, it may result in Attention Deficit Hyperactivity Disorder (ADHD).


Hair Loss

Hair loss is a common symptom of zinc deficiency and is caused by the formation of dandruff in the hair. As long as your hair is deprived of zinc, it will not grow normally. People with a long-term lack of zinc can even experience hair loss on other parts of the body. However, similar symptoms can also be a sign of an abundance of zinc in one’s system, this will also lead to hair loss.

Joint and Hip Pain

Painful hip and knee joints have been linked to zinc deficiency. Bones contain a large amount of zinc, and deficiency of this essential mineral will cause pain and other complications. Research has shown that a zinc deficiency can be more detrimental to bone development than general diet restriction.


Deficiency of zinc causes diarrhea, but the mechanism which causes this symptom is unknown. In some registered cases, the level of severity was lessened by nearly 15% with zinc supplementation. Zinc medications are easily available at medical stores, but they should only be taken after a consultation by a health practitioner.

Appetite Issues

Improper intake of zinc in the body may lead to a severe loss of appetite, which may then result in serious problems like anorexia (not to be confused with anorexia nervosa, which is an eating disorder stemming from a mental issue). Eating less causes malnutrition and lowers zinc intake, making the condition all the more dangerous as zinc levels continue to drop. A loss of appetite can result in weight loss or hinder the growth of new cells and tissues in the body. Children with a zinc deficiency when they are born may also be underweight. Moreover, a weak body weakened by malnutrition is more prone to infections and lower immunity levels.


Zinc is a necessary dietary mineral for a healthy body and its deficiency symptoms should not to be ignored. One should eat healthy foods such as pecans, cashews, and pine nuts as well as fish and eggs. Another way to overcome symptoms of this deficiency would be by taking zinc supplements under the supervision of a qualified medical practitioner.

*Editor’s Note: the symptoms of zinc deficiency were republished with permission from Click here to continue reading. 


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Dr. Joel Fuhrman
Family physician, NY Times best-selling author, nutritional researcher and expert on nutrition and natural healing.

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