The Development of Mini Kidneys
The NTU research team, led by the Lee Kong Chian School of Medicine (LKCMedicine), has developed these “mini kidneys” using stem cells derived from the skin cells of patients with PKD. These kidney organoids are kidney-like structures that imitate the structure and function of human kidneys to some extent. Unlike previous studies that grew mini kidneys in a dish, the NTU team took a more advanced approach by engrafting their mini kidneys into live mice. This method allowed them to replicate the complex pathological features of kidney disease more accurately, including blood flow, fluid movement, and cellular communication with other organs.
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