Chantel Brink

Chantel Brink

June 8, 2025

Researchers Identify Anxiety ‘Off’ Switch That Causes No Side Effects

Identifying a Specific Brain Circuit

Coronal brain slice showing projections from different visual areas in the cerebral cortex to the ventrolateral geniculate nucleus (vLGN). These pathways are part of the circuit identified as mediating the suppression of instinctive fear responses
Image Credit: Sainsbury Wellcome Centre

Researchers at Weill Cornell Medicine have pinpointed a distinct neural pathway that plays a crucial role in anxiety. This circuit involves the metabotropic glutamate receptor 2 (mGluR2), a receptor that modulates neuronal activity. By focusing on this receptor within a particular brain circuit leading to the amygdala, a key center for emotion processing, they found that manipulating this pathway can reduce anxiety behaviors.