The Role of mGluR2 as an Anxiety ‘Off’ Switch
The mGluR2 receptor acts like a “dimmer switch,” reducing synaptic transmission when activated. This modulation helps tone down anxiety responses without shutting down other brain functions. Previous studies showed mGluR2 activation could ease anxiety, but concerns about side effects limited drug development. The new research demonstrates that targeting mGluR2 in this specific circuit avoids those unwanted effects.
