Bruce Abrahamse

Bruce Abrahamse

March 11, 2025

Losing Just One Night of Sleep Can Weaken Your Immune System and Heighten Inflammation

Getting a good night’s rest is vital to your well-being and health. According to a new study, losing sleep can negatively impact your immune system. Additionally, it has been associated with the development of certain diseases, such as diabetes, heart disease, and obesity. In this article, we will look deeper into the effects that losing sleep has on your body.

What Losing Sleep Does To Your Body

tired man after losing sleep
Credit: Pixabay

The researchers found that even one 24-hour cycle without sleep in healthy young individuals altered their immune cell profiles. These immune cells help regulate the immune system, and they start to resemble those of an obese person. This reveals that our immune systems are very sensitive to sleep and can quickly adapt to sleep pattern changes. If these shifts are persistent, it could result in long-term inflammation that increases the risk of developing disease. 

Many studies have already revealed a link between sleep disturbances and various conditions like heart disease and type 2 diabetes. It has also been shown that chronic inflammation can result in poor health outcomes. However, not enough is yet known about the direct influence sleep has on immune cells such as monocytes. These cells are regarded as the body’s first line of defense, detecting pathogens quickly and initiating a response from the immune system. For the study, the researchers analyzed the sleeping patterns of 237 healthy individuals with varying BMIs. They also took blood samples to make note of the different monocyte levels and inflammation markers. 

Read More: How The Military Sleep Method Can Get You To Sleep In Two Minutes

Results of the Study on Losing Sleep 

tired man
Credit: Pixabay

The study revealed that the obese participants exhibited much lower sleep quality and more inflammation than the leaner participants. They also found that non-classical monocytes had also significantly increased. These particular monocytes usually patrol around our bodies, looking for and responding to inflammatory cues. Five of the leaner participants’ monocyte profiles had also changed after losing a night’s sleep and were now closer in profile to the obese participants. According to the study’s lead author Dr. Al-Rashed, “Our findings underscore a growing public health challenge. Advancements in technology, prolonged screen time, and shifting societal norms are increasingly disruptive to regular sleeping hours.”  It is quite evident from these studies that this disruption has significant implications for our immune health. 

The next step for the researchers is to learn more about the mechanisms that cause losing sleep to affect our immune systems the way it does. They would also like to learn if certain therapies and interventions may be able to potentially reverse these alterations in the immune system. Their long-term goal is for this research to inform policies that bring more recognition to the role sleep plays in maintaining overall health. They wish to see reforms in the workplace and are driven by campaigns that promote the benefits of better sleeping habits. This is especially crucial for people whose lifestyle and livelihoods result in them losing much precious sleep. According to Dr. Al-Rashed, “Ultimately, this could help mitigate the burden of inflammatory diseases like obesity, diabetes, and cardiovascular diseases.”

The Bottom Line on Losing Sleep and Your Health

woman sleeping
Credit: Pixabay

Losing even one night’s sleep can have a significant impact on your immune system. It increases inflammation and modifies immune cell activity in ways that may contribute to long-term health problems. This study emphasizes the important role that sleep plays in regulating immune responses.. As our modern lifestyles continue to disrupt healthy sleeping patterns, it is more crucial than ever that we prioritize rest. Future research may provide light on how to mitigate these negative consequences, but for the time being, getting enough sleep is still one of the best things you can do to strengthen your immune system.

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