Dr. Michael Newman, DNM, Ph.D, HHP, FAIS.
Dr. Michael Newman, DNM, Ph.D, HHP, FAIS.
September 12, 2024 ·  14 min read

6 Natural Remedies To Help With Depression and Anxiety That Most People Haven’t Heard Of

Depression, defined by (World Health Organization, n.d.-b) states, “Depressive disorder, or depression, is a common mental health condition that can happen to anyone. It is characterized by a low mood or loss of pleasure or interest in activities for long periods. This is different from regular mood changes and feelings about everyday life.”

While anxiety is defined by (American Psychological Association, n.d.) states,” Anxiety is an emotion characterized by feelings of tension, worried thoughts, and physical changes like increased blood pressure. Anxiety is not the same as fear, but they are often used interchangeably.”

Anxiety and depressive disorders are prevalent psychiatric conditions that frequently co-occur. Both conditions fall under the broader category of internalizing disorders. Moreover, it is common for individuals with an anxiety disorder, such as generalized anxiety disorder or panic disorder, to experience accompanying depression. Many individuals receive diagnoses of both an anxiety disorder and clinical depression simultaneously (Kalin, 2020).

How are Anxiety and Depression Treated Conventionally?

woman with melancholy stare looking out a window. Depression and mood disorder concept
Credit: Shutterstock

Anxiety disorders are among the most common psychiatric conditions, with generalized anxiety disorder, panic disorder/agoraphobia, and social anxiety disorder being the most prevalent. These conditions impose a significant burden of illness on those affected. Treatment for anxiety disorders may involve psychological therapy, medication, or a combination of both. Cognitive behavioral therapy is considered a highly effective form of psychotherapy, supported by solid evidence (Bandelow et al., 2017).

Depression is a global mental health disorder that has been shown to reduce the quality of life and disrupt normal functioning significantly. When treating a major depressive episode, the primary goal is to alleviate the patient’s symptoms, often through the use of pharmacotherapy. Selective serotonin reuptake inhibitors (SSRIs) are frequently prescribed as a first-line treatment for depression during the acute phase due to their effectiveness in managing symptoms. However, other emerging pharmacological options are also being explored for their potential in treating depression during the acute phase. In specific situations, electroconvulsive therapy is the most effective bodily therapy for depression. For individuals with resistant forms of depression, a combination of medications, psychotherapy, and somatic therapies is often the most effective approach to management (Karrouri et al., 2021).

Read More: Research Links IBS and Mental Health Disorders

What can be done from a food, lifestyle, supplemental and natural therapy perspective?

Salmon, shrimp, and omega 3 fish oil supplements. Sources of Omega 3
Credit: Shutterstock

Evidence-based Mood-Boosting Foods 

The relationship between food and mood is a fascinating topic of study. Studies show that our diet and nutrition can significantly impact our mental well-being. A balanced diet can contribute to positive moods and overall mental wellness. Poor dietary choices can cause fatigue, irritability, and other adverse effects on mental health. Understanding the relationship between what we eat and how we feel is essential for maintaining a healthy mind and body (Firth et al., 2020).

1. Omega-3 Rich Foods 

 Omega-3 fatty acids play a significant role in the structure of brain cell membranes and affect essential processes in the central nervous system. They can regulate the transmission of signals between neurons, influence the expression of genes, and directly impact the creation of new neurons and the survival of existing ones. Additionally, they exhibit antioxidant properties and anti-inflammatory solid effects, which are believed to contribute to their potential health-promoting properties. Early studies suggest that including omega-3-rich foods like eggs, nuts, seeds, seafood, and certain plant oils may offer various health benefits (Zeman et al., 2012).

2. Cold Water Fish 

Omega-3 fatty acids, specifically DHA and EPA, play a significant role in maintaining mental health and are mainly found in cold-water fatty fish such as mackerel, salmon, herring, and sardine. Consuming a diet rich in DHA can potentially improve your mood and decrease aggression, empowering you to take control of your mental health.

Furthermore, individuals with a high consumption of fish have reported lower rates of depression. Additionally, a small trial involving psychiatric patients showed that taking fish oil supplements led to a reduction in episodes of depression and mania (Ness et al., 2003).

3. Antioxidants

Numerous studies have shown that dietary patterns, like the Mediterranean diet, have been associated with a decreased risk of depression or depressive symptoms. Conversely, diets high in fat and sugar-sweetened beverages have been linked to a higher risk of depression. Moreover, antioxidants present in foods such as green tea and isoflavonoids such as soybeans, edamame, tofu, miso, tempeh and chickpeas have demonstrated the potential to lower the risk of depression and may also offer relief from anxiety. In summary, dietary patterns, specific foods, and antioxidants are crucial in preventing and treating depression (Huang et al., 2019).

Read More: 6 Ways to Stimulate Your Vagus Nerve That May Help Manage Depression, Inflammation, and More

Woman sitting looking at view of river and mountains
Credit: Shutterstock

In recent years, supplements have gained popularity due to their potential to promote psychological well-being and their well-known physical benefits. Many people have turned to supplements to help manage conditions such as anxiety and depression. However, consulting a healthcare professional before trying new supplements is vital. Some examples of well-known supplements promising in treating anxiety and depression include vitamin D3, magnesium, omega-3, and ashwagandha. These evidence-based supplements may offer additional options for those seeking to support their mental health. Some tremendous evidence-based supplements are not as well known, but studies show they are equally effective. 

1. Kava Kava

In a 2018 systematic review of clinical trials, it was discovered that Kava Kava can increase dopamine levels and interact with various receptors in the brain to alleviate symptoms of anxiety(Baum et al., 1998). It is particularly effective for short-term relief from stress, although it is not recommended for long-term use (Pittler & Ernst, 2003). Kava has shown the potential to reduce symptoms of generalized anxiety significantly (Pittler & Ernst, 2000). However, it is essential to exercise caution when using Kava in conjunction with other prescription medications.

2. Lemon Balm 

Lemon balm has demonstrated a promising potential for reducing stress, easing anxiety and depressive symptoms, and improving mood and attention, based on current evidence. These effects are particularly noteworthy in acute situations (Ghazizadeh et al., 2021). Lemon balm is available in capsule form, loose-leaf tea, tincture, or topical application. 

3. Passionflower 

Passionflower is a traditional herbal remedy known for its wide-ranging health benefits. It has been found to have anti-inflammatory, anti-asthmatic, antitussive, glucose-lowering, anticonvulsant, soothing, and anti-anxiety effects. In the past, passionflower was often used with other calming herbs, making it challenging to discern its individual effects. However, recent studies focusing on people with generalized anxiety disorder have indicated that passionflower is just as effective as the medication oxazepam (Serax) in alleviating symptoms. These findings suggest that Passiflora extract can be a valuable herbal option for managing generalized anxiety disorder (Akhondzadeh et al., 2001).

Read More: Probiotics & Mental Health: A Guide to Help With Brain, Mood, and Gut Health 

4. SAMe

Depression is a major worldwide health issue, and existing antidepressants have not been effective for many people. Research suggests that SAMe (S-adenosyl-L-methionine), used as a stand-alone treatment, may offer a moderate but noticeable improvement in reducing depressive symptoms. Due to its favorable tolerability, SAMe monotherapy should be taken into account as a potential treatment for individuals dealing with depression (Limveeraprajak et al., 2024). Be careful when using SAMe, as it has similar effects to many antidepressants and may over-stimulate your serotonin levels. Taking Parkinson’s disease medications with SAMe may make it less effective and lead to unwanted side effects. It can also increase the risk of bleeding, and if taken before surgery, it can alter your response to anesthesia.

5. Saffron

Extensive research has been conducted on saffron and its components, particularly regarding its potential as a treatment for depression and anxiety. Studies have shown that saffron can enhance the release of essential neurotransmitters like dopamine and glutamate in the brains of rats (Monchaux De Oliveira et al., 2021). Additionally, these studies have revealed that the extract’s impact on dopamine release is influenced by the dosage administered. Current research suggests that saffron shows promise in treating mild-to-moderate depression. More human studies are needed to deepen our understanding of saffron’s mechanisms of action and its potential efficacy in managing major depression (Siddiqui et al., 2018).

6. St John’s Wort

According to various studies, St. John’s wort has shown potential benefits for patients diagnosed with mild to moderate depression, with some research suggesting that it can be as effective as certain prescription antidepressants (Apaydin et al., 2016). However, for individuals meeting the criteria for major depression, current evidence indicates that the beneficial effects of St. John’s Wort are minimal. A study found that St. John’s wort was not considered a practical treatment for significant depression (Shelton et al., 2001).

Note that St. John’s wort has the potential to interact with medications used for treating depression or other mood disorders, such as tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), and monoamine oxidase inhibitors. 

Traditional Therapy vs Mindfulness Practice Modalities 

Talk therapy, or psychological therapy, encompasses a variety of therapeutic approaches aimed at addressing mental and emotional distress. Among the numerous types of psychotherapy, cognitive behavioral therapy (CBT) and Eye Movement Desensitization and Reprocessing (EMDR) have both been identified as particularly effective for treating depression. While there are other treatment options available, these two approaches are widely recognized and utilized by mental health professionals.

Read More: High-Functioning Depression: 16 Truths Sufferers Wish You Knew

Traditional Therapies

1. Cognitive Behavioural Therapy (CBT)?

The effectiveness of cognitive-behavioral therapy (CBT) in addressing stress and anxiety is well-established. CBT assists individuals in identifying and eliminating avoidance and safety-seeking behaviors. By challenging and correcting erroneous beliefs, CBT aids in the management of stress, ultimately contributing to improved mental well-being. This comprehensive review assesses the efficacy of CBT in mitigating stress-related conditions within both clinical and general populations (Nakao et al., 2021).

 2. Eye Movement Desensitization and Reprocessing (EMDR)

Eye Movement Desensitization and Reprocessing (EMDR) therapy is an evidence-based psychotherapy for posttraumatic stress disorder (PTSD). It is effective for adults and children (Smith et al., 2018).

After undergoing EMDR therapy, there were significant reductions in trauma symptoms, depression, and anxiety. Notably, trait anxiety was also significantly improved and maintained over time. This improvement was not observed with imaginal exposure therapy (Shapiro, 2014). 

Mindfulness Modalities

1. Meditation Practice 

Meditation is a practice that anyone can do, and it has been shown to reduce anxiety. A 2018 research article published in Mindfulness (Bamber & Morpeth, 2018) found that mindfulness meditation had “a large and significant effect” on relieving stress, based on a meta-analysis of 25 studies involving nearly 1,500 college students.

2. Deep Breathing (Breathwork) 

In a review (Malviya et al., 2022), eight studies supported the use of breathwork to reduce anxiety and depressive symptoms effectively. The review indicated that the results regarding the effectiveness of breathwork in reducing stress and depression are auspicious.

In another research study, various breathwork techniques were found to produce noteworthy enhancements in anxiety symptoms among individuals clinically diagnosed with anxiety disorders. Suggestions for future research involve refining and standardizing breathwork methods and procedures for treating anxiety disorders (Banushi et al., 2023).

3. Mindfulness-Based Stress Reduction (MBSR) and Mindfulness-Based Cognitive Therapy (MBCT)

Randomized controlled trials link mindfulness treatments (primarily MBSR and MBCT) to active control conditions, consistently showing that MBIs effectively treat a broad range of outcomes among diverse populations. These outcomes include symptoms such as anxiety, risk of relapse because of depression, stress, and psychological or emotional distress. The results by (Khoury et al., 2013) demonstrate that MBIs have been effective in reducing anxiety and depression symptoms, consistently outperforming non-evidence-based treatments and active control conditions such as health education, relaxation training, and supportive psychotherapy and performing comparably to cognitive-behavioral therapy (CBT) (Hofmann & Gómez, 2017).

Conclusion

Anxiety and depression can have a profound impact on individuals, affecting their day-to-day functioning and overall well-being. These mental health conditions can lead to challenges in maintaining healthy social relationships, performing well in academic or professional settings, and interacting positively with family, friends, and the broader community. Research suggests that the collective impact of anxiety and depression results in the loss of approximately 12 billion productive work days annually, which has a staggering economic cost of nearly US$1 trillion.

In this article, you will find a comprehensive overview of six lesser-known remedies for managing anxiety and depression, backed by promising effects on emotional disorders. These remedies include Kava Kava, lemon balm, passionflower, SAMe, saffron, and St. John’s wort. Additionally, the article explores the significant correlation between food choices and mood regulation, emphasizing the impact of omega-3-rich foods, cold water fish, and antioxidant-rich food sources on emotional well-being.

While traditional therapeutic approaches remain valuable, clinical studies have elucidated the compelling benefits of mindfulness practices, encompassing meditation and deep breathing techniques (Pranayama). These practices have been shown to enhance blood oxygenation, reduce blood pressure and heart rate, alleviate muscle tension, and effectively mitigate stress and anxiety.

I want to emphasize that you need professional medical consultation before you begin on any new supplement regimen, dietary modifications, or discontinuation of prescription medications.

Read More: People With Hidden Depression Can Display These 12 Symptoms

 Disclaimer: This information is not intended to be a substitute for professional medical advice, diagnosis or treatment and is for information only. Always seek the advice of your physician or another qualified health provider with any questions about your medical condition and/or current medication. Do not disregard professional medical advice or delay seeking advice or treatment because of something you have read here.

Sources

  1. Akhondzadeh, S., Naghavi, H. R., Vazirian, M., Shayeganpour, A., Rashidi, H., & Khani, M. (2001). Passionflower in the treatment of generalized anxiety: A pilot double-blind randomized controlled trial with oxazepam. Journal of Clinical Pharmacy and Therapeutics, 26(5), 363–367. https://doi.org/10.1046/j.1365-2710.2001.00367.x
  2. American Psychological Association. (n.d.). Psychology topic [Anxiety]. apa.org. Retrieved August 20, 2024, from https://www.apa.org/topics/anxiety#:~:text=Anxiety%20is%20an%20emotion%20characterized,they%20are%20often%20used%20interchangeably.
  3. Apaydin, E. A., Maher, A. R., Shanman, R., Booth, M. S., Miles, J. V., Sorbero, M. E., & Hempel, S. (2016). A systematic review of st. john’s wort for major depressive disorder. Systematic Reviews, 5(1). https://doi.org/10.1186/s13643-016-0325-2
  4. Bamber, M. D., & Morpeth, E. (2018). Effects of mindfulness meditation on college student anxiety: A meta-analysis. Mindfulness, 10(2), 203–214. https://doi.org/10.1007/s12671-018-0965-5
  5. Bandelow, B., Michaelis, S., & Wedekind, D. (2017). Treatment of anxiety disorders. Dialogues in Clinical Neuroscience, 19(2), 93–107. https://doi.org/10.31887/dcns.2017.19.2/bbandelow
  6. Banushi, B., Brendle, M., Ragnhildstveit, A., Murphy, T., Moore, C., Egberts, J., & Robison, R. (2023). Breathwork interventions for adults with clinically diagnosed anxiety disorders: A scoping review. Brain Sciences, 13(2), 256. https://doi.org/10.3390/brainsci13020256
  7. Baum, S., Hill, R., & Rommelspacher, H. (1998). Effect of kava extract and individual kavapyrones on neurotransmitter levels in the nucleus accumbens of rats. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 22(7), 1105–1120. https://doi.org/10.1016/s0278-5846(98)00062-1
  8. Firth, J., Gangwisch, J. E., Borsini, A., Wootton, R. E., & Mayer, E. A. (2020). Food and mood: How do diet and nutrition affect mental wellbeing? BMJ, m2382. https://doi.org/10.1136/bmj.m2382
  9. Ghazizadeh, J., Sadigh‐Eteghad, S., Marx, W., Fakhari, A., Hamedeyazdan, S., Torbati, M., Taheri‐Tarighi, S., Araj‐khodaei, M., & Mirghafourvand, M. (2021). The effects of lemon balm (melissa officinalis l.) on depression and anxiety in clinical trials: A systematic review and meta‐analysis. Phytotherapy Research, 35(12), 6690–6705. https://doi.org/10.1002/ptr.7252
  10. Hofmann, S. G., & Gómez, A. F. (2017). Mindfulness-based interventions for anxiety and depression. Psychiatric Clinics of North America, 40(4), 739–749. https://doi.org/10.1016/j.psc.2017.08.008
  11. Huang, Q., Liu, H., Suzuki, K., Ma, S., & Liu, C. (2019). Linking what we eat to our mood: A review of diet, dietary antioxidants, and depression. Antioxidants, 8(9), 376. https://doi.org/10.3390/antiox8090376
  12. Kalin, N. H. (2020). The critical relationship between anxiety and depression. American Journal of Psychiatry, 177(5), 365–367. https://doi.org/10.1176/appi.ajp.2020.20030305
  13. Karrouri, R., Hammani, Z., Benjelloun, R., & Otheman, Y. (2021). Major depressive disorder: Validated treatments and future challenges. World Journal of Clinical Cases, 9(31), 9350–9367. https://doi.org/10.12998/wjcc.v9.i31.9350
  14. Khoury, B., Lecomte, T., Fortin, G., Masse, M., Therien, P., Bouchard, V., Chapleau, M.-A., Paquin, K., & Hofmann, S. G. (2013). Mindfulness-based therapy: A comprehensive meta-analysis. Clinical Psychology Review, 33(6), 763–771. https://doi.org/10.1016/j.cpr.2013.05.005
  15. Limveeraprajak, N., Nakhawatchana, S., Visukamol, A., Siripakkaphant, C., Suttajit, S., & Srisurapanont, M. (2024). Efficacy and acceptability of s-adenosyl-l-methionine (same) for depressed patients: A systematic review and meta- analysis. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 132, 110985. https://doi.org/10.1016/j.pnpbp.2024.110985
  16. Malviya, S., Meredith, P., Zupan, B., & Kerley, L. (2022). Identifying alternative mental health interventions: A systematic review of randomized controlled trials of chanting and breathwork. Journal of Spirituality in Mental Health, 24(2), 191–233. https://doi.org/10.1080/19349637.2021.2010631
  17. Monchaux De Oliveira, C., Pourtau, L., Vancassel, S., Pouchieu, C., Capuron, L., Gaudout, D., & Castanon, N. (2021). Saffron extract-induced improvement of depressive-like behavior in mice is associated with modulation of monoaminergic neurotransmission. Nutrients, 13(3), 904. https://doi.org/10.3390/nu13030904
  18. Nakao, M., Shirotsuki, K., & Sugaya, N. (2021). Cognitive–behavioral therapy for management of mental health and stress-related disorders: Recent advances in techniques and technologies. BioPsychoSocial Medicine, 15(1). https://doi.org/10.1186/s13030-021-00219-w
  19. Ness, A. R., Gallacher, J. E., Bennett, P. D., Gunnell, D. J., Rogers, P. J., Kessler, D., & Burr, M. L. (2003). Advice to eat fish and mood: A randomised controlled trial in men with angina. Nutritional Neuroscience, 6(1), 63–65. https://doi.org/10.1080/1028415021000056069
  20. Pittler, M. H., & Ernst, E. (2000). Efficacy of kava extract for treating anxiety: Systematic review and meta-analysis. Journal of Clinical Psychopharmacology, 20(1), 84–89. https://doi.org/10.1097/00004714-200002000-00014
  21. Pittler, M. H., & Ernst, E. (2003). Kava extract versus placebo for treating anxiety. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.cd003383
  22. Shapiro, F. (2014). The role of eye movement desensitization and reprocessing (emdr) therapy in medicine: Addressing the psychological and physical symptoms stemming from adverse life experiences. The Permanente Journal, 18(1), 71–77. https://doi.org/10.7812/tpp/13-098
  23. Shelton, R. C., Keller, M. B., Gelenberg, A., Dunner, D. L., Hirschfeld, R., Thase, M. E., Russell, J., Lydiard, R., Crits-Christoph, P., Gallop, R., Todd, L., Hellerstein, D., Goodnick, P., Keitner, G., Stahl, S. M., & Halbreich, U. (2001). Effectiveness of st john’s wort in major depression. JAMA, 285(15), 1978. https://doi.org/10.1001/jama.285.15.1978
  24. Siddiqui, M., Saleh, M. M., Basharuddin, S., Zamri, S., Mohd Najib, M., Che Ibrahim, M., binti Mohd Noor, N., Binti Mazha, H., Mohd Hassan, N., & Khatib, A. (2018). Saffron (crocus sativus l.): As an antidepressant. Journal of Pharmacy And Bioallied Sciences, 10(4), 173. https://doi.org/10.4103/jpbs.jpbs_83_18
  25. Smith, P., Dalgleish, T., & Meiser‐Stedman, R. (2018). Practitioner review: Posttraumatic stress disorder and its treatment in children and adolescents. Journal of Child Psychology and Psychiatry, 60(5), 500–515. https://doi.org/10.1111/jcpp.12983
  26. World Health Organization. (n.d.-a). Health Topic [Depression]. Retrieved August 28, 2024, from https://www.who.int/health-topics/depression#tab=tab_1
  27. World Health Organization. (n.d.-b). Health Topic [Depression]. who.int. Retrieved August 20, 2024, from https://www.who.int/health-topics/depression#tab=tab_1
  28. Zeman, M., Jirak, R., Raboch, J., & Zak, A. (2012). N-3 polyunsaturated fatty acids in psychiatric diseases: mechanisms and clinical data. Neuro endocrinology letters,, 33(8), 736–748. https://pubmed.ncbi.nlm.nih.gov/23391975/


     Disclaimer: This information is not intended to be a substitute for professional medical advice, diagnosis or treatment and is for information only. Always seek the advice of your physician or another qualified health provider with any questions about your medical condition and/or current medication. Do not disregard professional medical advice or delay seeking advice or treatment because of something you have read here.