Remarkable Results in Mouse Models
In a three-month trial, researchers gave diAcCA three times weekly to mice genetically modified to develop Alzheimer’s-like symptoms. Researchers gave olive oil to the other mouse models. During cognitive and behavioral tests, the treated mice showed not only a regression of inflammation and subsequently treating the conditions of Alzheimers, but restoration of memory.
The behavioral tests done on the mice included navigating water mazes and recalling fear-associated sounds. Their brain tissue analysis revealed increased synaptic density, in which their synapses returned to healthy levels. Researchers also noticed a significant drop in amyloid-beta plaques and phosphorylated tau tangles, proteins associated with causing Alzheimer’s and neuroinflammation. “It didn’t just slow the decline; it improved virtually back to normal,” said Dr. Stuart Lipton, lead researcher and neuroscientist at Scripps. The mice also took to the treatment well, with no toxic effects observed from the derivative.