How Ozempic Works in the Rebound Effect: What Happens When You Stop
Research shows about 70 percent of people discontinue the treatment around the two-year mark. Typically, this often happens because it becomes less effective at controlling cravings over time. A 2022 clinical trial tracked approximately 200 individuals who had taken semaglutide for over a year. After stopping, they regained about 12 percent of their body weight within just 12 months. Similarly, University researchers found that most people who discontinued the treatment regained roughly two-thirds of their lost weight.
“While muscle and bone mass might never return, the body has no trouble regaining fat mass,” experts explain. In addition, some research suggests certain formulations may actually stimulate new fat cell production.