Catherine Vercuiel

Catherine Vercuiel

March 6, 2025

10 Warning Signs of Peripheral Artery Disease To Look Out For

Peripheral Artery Disease (PAD) is a circulation problem where narrowed arteries reduce blood flow to your limbs. PAD affects millions of Americans, more than those currently living with cancer. Yet even though it’s so common, this condition often goes unnoticed until it’s caused huge problems. 

What Exactly Is Peripheral Artery Disease?

Diagram showing blood vessels in the leg, highlighting areas affected by Peripheral Artery Disease.
Credit: Wikimedia Commons

In simple terms, Peripheral Artery Disease (PAD) is a circulatory problem where narrowed arteries reduce blood flow to your limbs, most commonly the legs. It’s caused by atherosclerosis, the same process that leads to coronary artery disease. Fatty deposits build up in your artery walls, restricting blood flow and depriving your muscles and tissues of the oxygen they desperately need.

Think of your arteries like water pipes. When sediment and mineral deposits build up inside, water flow becomes restricted. Similarly, when plaque builds up in your arteries, blood flow becomes limited, depriving your tissues of the oxygen they need.

Why Should You Care About PAD?

A thought-provoking image exploring the significance of the word "why" in its connection to Peripheral Artery Disease.
Credit: Pexels

The real shocker is that Peripheral Artery Disease (PAD) doesn’t just affect your legs. It’s a sign that atherosclerosis might be happening throughout your body, including arteries that supply blood to your heart and brain. This means people with PAD have a significantly higher risk of heart attack and stroke.

Also, severe PAD can lead to tissue death, chronic wounds, and in extreme cases, amputation. Now, let’s talk about the 10 warning signs you can look out for.

1. Leg Pain During Activity 

A person grimacing while holding their knee, showing signs of pain from Peripheral Artery Disease symptoms.
Credit: Unsplash

This is the classic Peripheral Artery Disease symptom that affects many patients. You’re walking along just fine, then suddenly your calf, thigh, or buttocks start cramping or aching. The discomfort builds until you stop walking, then it fades away as you relax. This happens because your muscles need more oxygen during exercise, but your narrowed arteries can’t deliver enough blood to meet the demand.

2. Numbness or Weakness in the Legs

Asian woman holding the calf with pain. Female suffering from pain in leg at home. Health care concept.
Source: Shutterstock

Does your leg sometimes feel like it’s falling asleep for no reason? PAD can cause decreased sensation, weakness, or a pins-and-needles feeling in your lower extremities. This numbness occurs because your nerves aren’t getting the blood supply they need to function properly.

3. Shiny, Smooth Skin on Your Legs

A man in the grass grips his knee, his skin appearing smooth and shiny, possibly signaling underlying health concerns.
Credit: Pexels

Take a look at your legs. Is the skin unusually smooth, shiny, or tight? When arteries are blocked, your skin doesn’t receive enough nutrients and oxygen, causing changes in its appearance and texture. It’s your body’s external signal that something’s going wrong internally.

4. Hair Loss on Your Feet and Legs

Close-up of a person's arm showing a small patch of skin, highlighting potential signs of hair loss and health concerns.

Have you noticed that the hair on your lower legs or feet has mysteriously disappeared? Hair follicles are particularly sensitive to reduced blood flow. When they don’t get enough nutrients, they can’t support hair growth. Patchy or complete hair loss on your legs, especially when combined with other symptoms, could be a telltale sign of Peripheral Artery Disease.

Read More: Regular Nut Consumptions Helps Ward Off Dementia and Disease

5. Slow-Healing Wounds

Plasters stuck on a blue background, symbolizing how wounds need oxygen and nutrients for effective healing.

Have you ever cut or scraped your foot and it just won’t heal? Reduced blood flow seriously slows down your body’s natural healing process. Even minor injuries can become stubborn wounds when your tissues aren’t receiving enough oxygen and nutrients to repair themselves.

6. Skin Discoloration

Illustration of an occluded artery in the lower leg caused by an old organized thrombus, depicting a common complication of peripheral vascular disease (PVD).
Credit: Wikimedia Commons

If your legs or feet look pale, bluish, or reddish even when elevated, PAD could be the culprit. This discoloration happens because not enough blood is reaching your extremities, causing visible changes in skin color that may worsen with position changes.

7. Cold Feet or Legs (Especially One Colder Than the Other)

A pair of left and right socks, highlighting the temperature difference often felt in feet due to circulation issues.
Credit: Unsplash

Have you ever experienced your feet or legs feeling suddenly cold, particularly compared to the rest of your body? Or is one foot consistently colder than the other? Reduced blood flow means less warmth reaching your extremities. This temperature difference can be particularly noticeable when comparing one side to the other.

8. Weak or Absent Pulses in Your Feet

Close-up of a paper displaying an ECG, highlighting key indicators of blood flow issues in peripheral artery disease.
Credit: Pexels

While this isn’t something you might notice yourself, it’s a key sign healthcare providers look for. Weakened or absent pulses in the feet indicate that blood isn’t flowing normally through those arteries, a classic indicator of PAD that your doctor can easily check.

9. Changes in Toenail Growth

An individual carefully cutting their  toenail, emphasizing the need for good blood supply for optimal nail health.
Credit: Pexels

PAD can cause your toenails to grow more slowly or become thickened and distorted. Like hair follicles, your nails need good blood supply to develop normally. When that supply is compromised, your nail health suffers.

10. Erectile Dysfunction in Men

A pair of jeans with a banana peeking out of the pocket, erectile dysfunction symbolizing erectile dysfunction.
Credit: Pixabay

This might seem unrelated, but PAD can affect arteries throughout the body. In men, reduced blood flow to the pelvic area can cause erectile dysfunction, often before leg symptoms become obvious. It’s part of a condition called Leriche syndrome, where PAD affects the arteries in the lower abdomen and pelvis.

Who’s at Risk for PAD?

A lit cigarette emits a plume of smoke, creating a hazy atmosphere around it.
Credit: Pexels

You’re more likely to develop PAD if you:

  • Smoke (this is the biggest controllable risk factor)
  • Have diabetes
  • Have high blood pressure
  • Have high cholesterol
  • Are over 60
  • Have a family history of PAD or other cardiovascular diseases
  • Are overweight or obese
  • Live a sedentary lifestyle

What Should You Do if You Suspect PAD?

A male doctor wearing a blue shirt and glasses, standing confidently in a medical setting.
Credit: Unsplash

If you’re experiencing any of these symptoms, especially leg pain with activity that goes away with rest, it’s time to talk to your doctor. Diagnosis typically starts with a simple test called an ankle-brachial index (ABI), which compares the blood pressure in your ankle to the blood pressure in your arm.

PAD is treatable, especially when caught early. Treatment options include:

  • Lifestyle changes (quitting smoking, regular exercise, and healthy eating)
  • Medications to lower cholesterol, control blood pressure, and prevent blood clots
  • Supervised exercise programs
  • Procedures to restore blood flow in severe cases

Please Don’t Wait Until It’s Too Late

A solitary pink rose blooms in darkness, its delicate petals contrasting with the surrounding shadows.
Credit: Pixabay

The tricky thing about PAD is that symptoms often come and go, making it easy to dismiss them. You might feel that cramping during your walk, but once you rest and the pain subsides, you forget about it until the next time. The issue is PAD is a progressive disease that typically worsens without treatment. Remember, it’s not just about your legs. PAD indicates a higher risk for heart attack and stroke, so addressing it promptly protects your entire cardiovascular system.

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