1. Leg Pain During Activity
This is the classic Peripheral Artery Disease symptom that affects many patients. You’re walking along just fine, then suddenly your calf, thigh, or buttocks start cramping or aching. The discomfort builds until you stop walking, then it fades away as you relax. This happens because your muscles need more oxygen during exercise, but your narrowed arteries can’t deliver enough blood to meet the demand.
