Bruce Abrahamse

Bruce Abrahamse

May 11, 2025

At Age 50, These 5 Factors Could Cut a Decade From Your Lifespan

A German study has recently revealed 5 midlife health risks that could cut a decade off your lifespan. Recently presented at the American College of Cardiology Scientific Session, the study identified obesity, diabetes, high cholesterol, smoking, and high blood pressure as the risk factors. Collectively, these factors account for an astounding 50% of all cardiovascular diseases. The aim of the study was to determine how many additional years were achievable if these factors were modified or absent in middle age. Published in the New England Journal of Medicine, the findings revealed that making the appropriate lifestyle changes in middle age could make a significant difference in lifespan. Quitting smoking and lowering blood pressure exhibited the most significant impact on lifespan. 

The Power of Making Healthy Lifestyle Changes 

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The study has revealed that individuals can make lifestyle changes at 50 that significantly lower midlife health risks. Doctors recommend that individuals aged 50 go for a simple examination that can predict the risk of various cardiovascular diseases, such as stroke and heart attacks. For the study, the research group analyzed the health data of more than 2 million people from 39 different countries. They specifically looked for 50 year old individuals who had high cholesterol, diabetes, smoked, were obese or underweight, and had high blood pressure. These participants were then periodically followed up for up to 47 years. The study allowed for the risk prediction up to 90 years of age. 

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Results of the Midlife Health Risks Study

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The researchers discovered that the risk of developing cardiovascular disease over a lifetime was considerable. The risk was found to be 21% for men and 13% for women. However, when all five midlife health risks were present, these percentages shot up considerably. The risk of lifetime cardiovascular disease rose to 38% in men and 24% in women. For the female participants who had all five factors at 50, cardiovascular diseases arose 13 years earlier compared to those without the risk. For the male participants, these issues arose almost 11 years earlier. When it came to mortality risk, the risk of death without these factors was 68% in men and 53% in women. When the midlife health risks were present, this number rose to 94% in men and 88% in women. 

Crucial Lifestyle Interventions

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Luckily, the study also revealed that these health outcomes are not predetermined. By addressing these midlife health risks and changing lifestyle habits, these risks could be significantly reduced, even at the age of 50. The researchers noted that the most effective interventions were quitting smoking and lowering blood pressure. Lowering blood pressure at middle age was linked to a delay in the onset of cardiovascular events by 1.2 years for men, and 2.4 years for women. Quitting smoking could potentially add 2.4 years to men’s lifespans, and 2.1 to women’s. The more of these midlife health risks addressed, the more years added to a patient’s lifespan. Changing all five risk factors was linked to an additional 5 years of life. 

Limitations of The Study

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The study showed varying degrees of cardiovascular disease risk when it came to body mass index and cholesterol. This made it hard to adjust for these factors statistically. Additionally, the fact that the data was sourced from such a global dataset provided both advantages and challenges. The data could have been collected in different ways in each region and examined under varying conditions. This meant that the study’s authors had to include certain mathematical equations based on assumptions, called ‘harmonization’. This may explain why this particular study reached the conclusion that the five midlife health risks only accounted for 50%. Previous studies had found the number to be significantly higher.

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Focusing on Preventative Measures

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Based on their findings, the researchers have suggested that targeted interventions for specific risk factors are the best move forward. Smoking and high blood pressure, particularly, should be the main focus of lifestyle intervention. These findings are particularly pertinent to the German people themselves, where the main midlife health risks are more prevalent than in other countries in Europe. According to Holger Thiele, MD, PhD, director of the Heart Center Leipzig at the University of Leipzig, “The approach to the Healthy Heart Act was already moving in the correct direction. This now needs to be incorporated into a new coalition agreement and developed into a national cardiovascular strategy focusing on individual prevention with early detection measures and structural interventions”.  

The Bottom Line

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This study provides a clear message: it’s not too late to undertake lifestyle changes that could greatly lengthen your life. Even people who are currently struggling with health issues might regain valuable years by addressing significant midlife health risks. The statistics demonstrate that addressing these five factors can postpone cardiovascular disease and lower the chance of premature mortality. While no study is without flaws, the overall conclusion is compelling: minor, focused lifestyle adjustments in midlife can have a long-term influence. For many people, this could be the most essential investment they ever make—not just for their lifespan, but also for a healthier, more vibrant future.

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